Crispr Therapeutics Down 4% On Earnings Miss; Street Stays Bullish

<p class="canvas-atom canvas-text Mb(1.0em) Mb(0)–sm Mt(0.8em)–sm" type="text" content="Shares in Crispr Therapeutics (CRSP) fell 4% in Monday’s after-hours trading, after the gene-focused biopharma reported disappointing second quarter earning results.” data-reactid=”12″>Shares in Crispr Therapeutics (CRSP) fell 4% in Monday’s after-hours trading, after the gene-focused biopharma reported disappointing second quarter earning results.

Specifically, second quarter GAAP EPS of -$1.30 fell short of Street estimates by $0.39 while collaboration revenue of $0.04M missed by $19.73M. The revenue also represented a significant year-over-year drop of 87.5%. CRSP also reported cash and cash equivalents of $945.1M.

Crispr also gave a few business updates, revealing that:

1) dosing has resumed in ongoing CTX001 Ph1/2 trials for hemoglobinopathies (SCD & ß-Thalassemia), and CRSP expects new data in 2020;

2) CTX110 enrollment remains ongoing and CRSP expects topline data from the open-label study by YE20;

3) CTX120 study in r/r-MM continues dosing and could have data in 1H21;

4) CTX130 clinical studies in solid and hematological tumors initiated with data expected in 2021; and

5) CRSP entered a research collaboration with UHN expanding the company’s regenerative medicine portfolio.

<p class="canvas-atom canvas-text Mb(1.0em) Mb(0)–sm Mt(0.8em)–sm" type="text" content="Following the report, Oppenheimer analyst&nbsp;Jay Olson&nbsp;reiterated his buy rating on the stock with a price target of $109 up from $89 previously. With shares up 51% year-to-date, his new price target indicates upside potential of 14%.” data-reactid=”24″>Following the report, Oppenheimer analyst Jay Olson reiterated his buy rating on the stock with a price target of $109 up from $89 previously. With shares up 51% year-to-date, his new price target indicates upside potential of 14%.

“We update our model with a 75% PoS [probability of success] estimate for CTX001 driving our new $105 PT” the analyst explained, adding that he is impressed by the continued progress of studies as they overcome COVID-19 challenges.

<p class="canvas-atom canvas-text Mb(1.0em) Mb(0)–sm Mt(0.8em)–sm" type="text" content="CTX001 is an investigational&nbsp;ex vivo&nbsp;CRISPR gene-edited therapy that is being evaluated for patients suffering from TDT or severe SCD in which a patient’s hematopoietic stem cells are engineered to produce high levels of fetal hemoglobin (HbF; hemoglobin F) in red blood cells.” data-reactid=”26″>CTX001 is an investigational ex vivo CRISPR gene-edited therapy that is being evaluated for patients suffering from TDT or severe SCD in which a patient’s hematopoietic stem cells are engineered to produce high levels of fetal hemoglobin (HbF; hemoglobin F) in red blood cells.

“Overall, we view CRSP’s development strategy as well thought out: the Clinical pipeline is most focused on improving “established” approaches via CRISPR while more complex projects (in vivo editing) are pursued in a second wave” the analyst continued.

<p class="canvas-atom canvas-text Mb(1.0em) Mb(0)–sm Mt(0.8em)–sm" type="text" content="Indeed, the Street has a bullish&nbsp;Strong Buy&nbsp;consensus on CRSP stock with an average analyst price target of $93 (1% upside potential).&nbsp;(See CRSP stock analysis on TipRanks)” data-reactid=”28″>Indeed, the Street has a bullish Strong Buy consensus on CRSP stock with an average analyst price target of $93 (1% upside potential). (See CRSP stock analysis on TipRanks)

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